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BIOCHEMIST (protein and small molecule assay development)

Full-time

Primary Responsibilities:

  • Investigate, develop and execute assay development and biomolecular analysis both on the bench and transfer protocols to our custom platform (focus on protein, small molecule, and electrolytes)

  • Perform experiments and assays to support product troubleshooting and QC.

  • Develop and execute Standard Operating Procedures (SOPs) to prepare buffers, reagents and Immunoassay kits

Qualifications and Desired Skills:

  • Ph.D. in biochemistry, molecular biology, or other related degree concentration, with 2-5 years of industrial experience with a focus on protein, small-molecule and electrolyte assay development.

  • Strong foundation in protein science and protein characterization.

  • Experience with Immunoassay development including optimization, validation, antibody selection, and conjugation is required.

  • General wet lab skills and techniques such as gel electrophoresis, western blot, ELISA,  EMSA, flow cytometry, cell handling, pipetting, UV/Vis spectroscopy, microscopy, etc. is required

  • Experience with analytical techniques such as FTIR, Cyclic voltammetry, Amperometry, XPS, NMR, HPLC, Mass Spectrometry

  • Bioconjugation technique, eg, protein-protein, protein-DNA, monoclonal antibodies, fluorescence labeling, antibody, and protein biotinylation

  • Experience with surface chemistry, surface functionalization, electrochemistry techniques, and microfluidics is a plus

  • Experience with aptamers selection, aptamer-protein conjugation assays is a significant plus.

  • Ability to conduct process characterization and process validation experiments, design-of-experiment robustness studies, as well as assay qualification studies

  • Strong data analysis and troubleshooting skills (Excel, Python, and Statistics) is required

  • Ability to conduct parallelize experiments to optimize test conditions and protocols based on design of experiments (DOE).

  • Strong verbal and written communication skills are required